2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Chloride Cotransporter (NCC)

Sodium Chloride Cotransporter (NCC) 

Sodium Chloride Cotransporter

Sodium chloride cotransporter (NCC), encoded by the SLC12A3 gene, is a member of the electroneutral cation–chloride cotransporter (CCC) family. NCC mediates Na+ and Cl− cotransport following a 1:1 stoichiometry.
NCC is a homodimer formed by two subunits. NCC-mediated ion transport is activated through the phosphorylation of conserved threonine and serine residues in the cytosolic N-terminal domain of the transporter.
Sodium chloride cotransporter (NCC) mediates the reabsorption of ultrafiltered sodium in the renal distal convoluted tubule that is essential for electrolyte balance, blood pressure regulation, and the pathophysiology of hypertension[1].

Sodium Chloride Cotransporter (NCC) 相关产品 (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-15833
    Chlorthalidone

    氯噻酮

    		Inhibitor 99.76%
    Chlorthalidone 是一种噻嗪类利尿剂，有潜力用于高血压的研究。
    Chlorthalidone
  • HY-B1477
    Clopamide

    氯帕胺

    		Inhibitor 99.0%
    Clopamide 是一种具有口服活性的噻嗪类利尿剂，可抑制钠耦合的氯离子共转运蛋白 SLC12A3。Clopamide 可用于高血压和心力衰竭的研究。
    Clopamide
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z